Original Mildronate® from Grindex/Latvia

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  • Riga, Latvia

Instruction


Instruction for use
Mildronate® 500mgx60N
Drug formulation: Active substance: meldonium phosphate; 1 tablet contains meldonium phosphate (in terms of meldonium) 500 mg; Adjuvants: mannitol (e 421),povidone k29/32, potato starch, silicon dioxide, microcrystalline cellulose, magnesium stearate;
Indications.
  • decreased working efficiency, intellectual and physical overstress (including in athletes);
  • for combined therapy of ischemic heart disease (stenocardia, myocardial infarction), chronic cardiac decompensation, and dyshormonal cardiomyopathy;
  • for combined therapy of chronic disturbances of brain blood supply (cerebral strokes, and cerebrovascular insufficiency);
  • diseases of peripheral arteries (DPA);
  • abstinence syndrome in case of chronic alcoholism (in combination with specific alcoholism therapy).
Contraindications.
Hypersensitivity to meldonium or any components of the drug.
Increased intracranial pressure (in case of impaired venous drainage, intracranial
tumours). Pregnancy and breast-feeding periods. Children’s age.
Method of application and dosage.
Applied internally.
  • Intellectual and physical stress (including in athletes). Adults – 1 g per day divided into two 500mg doses. Course of treatment is 10-14 days. If necessary, the treatment is repeated in 2-3 weeks.
  • Athletes should take 500 mg – 1 g twice a day before training. Duration of treatment during preparatory period is 2-3 weeks, during the period of competition – 10-14 days.
  • Cardiovascular disease. As part of combined therapy: 500 mg -1 g (1-2 tablets) per day, taking the whole dose at one time or dividing for 2 takings. Course of treatment is 4-6 weeks.
  • Cardialgia against the background of dyshormonal myocardiodystrophy – 500 mg per day. Course of treatment is 12 days.
  • Disturbed cerebral circulation. In course of treatment after elimination of acute disorders: 500 mg – 1 g per day, taking the whole dose at one time or dividing it for 2 takings. In case of chronic disorders: 500 mg per day. General course of treatment is 4-6 weeks. Recurrent courses (usually 2-3 times a year) may be taken after consulting a doctor.
  • Diseases of peripheral arteries. 500 mg twice a day.
  • Abstinence syndrome in case of chronic alcoholism. 500 mg 4 times a day. Course of treatment is 7-10 days.
  • Maximum daily dose is 2000 mg.
Side effects.
Rarely – allergic reactions (redness, rash, itching, oedema), as well as dyspepsia, tachycardia, excitement, changes of arterial pressure.
Overdosage.
There is no data of cases of Mildronate® 500mg overdosage. The drug is low-toxic and does not cause any side effects which may threaten the health of patients. .
Application during pregnancy and breast-feeding periods.
Safety of Mildronate®  application during the pregnancy period has not been proved. In order to avoid possible negative effect of the drug on foetus, it should not be applied during pregnancy. It is unknown whether the drug penetrates into breast milk. If mother requires treatment with Mildronate®, breast-feeding shall be stopped.
Children.
There is no sufficient data about application of Mildronate®  for treatment of children.
Peculiarities of application.
Patients with chronic liver and renal diseases should take care in case of long-term application of the drug. Due to possible development of stimulating effect it is recommended to take the drug before noon. Ability to affect rate of reactions when driving or operating other mechanisms. There is no data about Mildronate®500mg negative effect on rate of reactions.
Interaction with other drugs and other types of interaction.
The drug may be combined with antianginal agents, anticoagulants and antiaggregants,
antiarrhythmic drugs, diuretics, and bronchial spasmolytics. It intensifies the action of coronary vasodilating drugs, some hypotensive agents, and cardiac glycosides. Taking into consideration the possible development of mild tachycardia and arterial hypotension, care should be taken when combining the drug with nitroglycerin, nifediphine, alpha-adrenoceptor blockers, hypotensive agents and peripheral vasodilators.
Pharmacological properties.
Pharmacodynamics. Mildronate®  is a structural analogue of gammabutyrobetaine, a substance contained in every cell of human organism. Under the conditions of excessive stress meldonium restores balance between oxygen supply and its demand in cells, and removes toxic metabolic products accumulated in cells protecting them from damage; it also possesses tonic effect. In the result of its application the organism receives the possibility to withstand stress and quickly restore its energy reserves. Thanks to these properties Mildronate® is used for treatment of various cardiovascular system disorders and brain circulation impairment, as well as for improvement of physical and intellectual working efficiency. Decrease in carnitine concentration results in intensification of synthesis of γ-butyrobetaine which possesses vasodilating properties. In case of acute ischemic damage of myocardium, meldonium decelerates formation of necrotic zone, and reduces the duration of rehabilitation period. In case of chronically impaired cardiac function, it improves contractive ability of myocardium, increases tolerance to physical stress, and reduces frequency of stenocardia attacks. In case of acute and chronic ischemic disturbances of cerebral circulation, it improves blood circulation in ischemia focus, and stimulates the redistribution of cerebral blood flow for the benefit of ischemic area. The drug eliminates functional disorders of nervous system in patients with chronic alcoholism in case of abstinence syndrome.
Pharmacokinetics.
After having been taken orally, the drug is rapidly absorbed. Its bioavailability is 78%. Maximum concentration in blood plasma is reached in 1-2 hours after intake. It is metabolised mainly in liver with further formation of two basic metabolites excreted by kidneys. Period of half-excretion when taken internally depends on the dose and is 3-6 hours.
Pharmaceutical characteristics.
Main physicochemical properties: white biconvex tablets, oval-shaped.
Effective period
3 years.
Do not apply the drug after the expiration date indicated on the packaging.
Storage conditions.
Store in dry place under the temperature below 25°C.
Store in place out of reach of children.
Packaging.
10 tablets in aluminum-foil blister.
6 blisters in carton.

Instruction

F.A.Q


Information about shipping and returns

Fast Free Shipping Worldwide (by Latvia Post). Shipping time - 3-20 business days (depend from region). Handling time - 1 business day. Tracking number ( will send via Paypal the same day).
RETURNS
Any packages returned back to us by the customs will be eligeble for a refund minus the P&P costs. Due to the nature of the product we cannot accept returns. Your statutory rights are not affected.

Is Mildronate Meldonium legit?

MILDRONATE® is  a licensed medical drug used widely throughout Eastern Europe and Central Asia for a number of conditions, including cardiac complaints. Meldonium is not licensed for use in the US, but it is class 5 medical (like dietary supplements for humans).
MILDRONATE® 250mgx20N is non-prescription medical (so - it is allowed to ship worldwide).

Why to buy MILDRONATE®?

MILDRONATE® made by Grindex is the best Meldonium source (by experience and reviews). With sales of the drug reaching 56 million euros in 2013, it is one of Latvia's biggest medical exports. According to the drug's designer, Ivar Kalvins - chair of the scientific board of the Latvian Institute of Organic Synthesis - it was created to increase the body's oxygen-carrying capacity.

Uses of Meldonium (Mildronate)

Meldonium is a fatty acid oxidation inhibitor and, today, it is principally used to treat angina and heart attacks (myocardial infarction). Its therapeutic activity is produced by altering pathways for carnitine, a nutrient involved in fat metabolism.3
A study in 2005 found that meldonium, in combination with an angiotensin-converting enzyme inhibitor called lisinopril, improved exercise capability and peripheral circulation for individuals with chronic heart failure.
A Chinese study group then tested meldonium for its efficacy in treating acute ischemic stroke, finding it as useful as cinepazide, a vasodilator commonly used to treat acute cerebral infarction.
Other uses for meldonium include:
  • Immune system modulation
  • Treating stomach ulcers
  • Treating eye trauma
  • Treating infections of the lungs and upper respiratory tract.